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The evolution of a-esterase mediated organophosphate resistance in Musca domestica

Claudianos, Charles


Ten carboxylesterase genes were cloned and sequenced from the house fly Musca domestica, and were found to be related to a-esterase genes in Drosophila melanogaster and Lucilia Cuprina. Gene sequence comparisons indicated that a series of gene duplication events occurred in the evolution of the a-esterase cluster in the Diptera that must have preceded the divergence of the Drosophilidae and Muscoidea, 80-100 Mya. An encompassing carboxylesterase phylogeny from bacteria to humans and a...[Show more]

CollectionsOpen Access Theses
Date published: 1999-06
Type: Thesis (PhD)


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