The evolution of a-esterase mediated organophosphate resistance in Musca domestica
Ten carboxylesterase genes were cloned and sequenced from the house fly Musca domestica, and were found to be related to a-esterase genes in Drosophila melanogaster and Lucilia Cuprina. Gene sequence comparisons indicated that a series of gene duplication events occurred in the evolution of the a-esterase cluster in the Diptera that must have preceded the divergence of the Drosophilidae and Muscoidea, 80-100 Mya. An encompassing carboxylesterase phylogeny from bacteria to humans and a...[Show more]
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