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Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography

Correy, Galen J; Carr, Paul D; Meirelles, Tamara; Mabbitt, Peter D; Fraser, Nicholas J; Weik, Martin; Jackson, Colin J


The proper function of enzymes often depends upon their efficient interconversion between particular conformational sub-states on a free-energy landscape. Experimentally characterizing these sub-states is challenging, which has limited our understanding of the role of protein dynamics in many enzymes. Here, we have used a combination of kinetic crystallography and detailed analysis of crystallographic protein ensembles to map the accessible conformational landscape of an insect carboxylesterase...[Show more]

CollectionsANU Research Publications
Date published: 2016-06-07
Type: Journal article
Source: Structure
DOI: 10.1016/j.str.2016.04.009


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