Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography
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Correy, Galen J.; Carr, Paul D.; Meirelles, Tamara; Mabbitt, Peter; Fraser, Nicholas J.; Weik, Martin; Jackson, Colin J.
Description
The proper function of enzymes often depends upon their efficient interconversion between particular conformational sub-states on a free-energy landscape. Experimentally characterizing these sub-states is challenging, which has limited our understanding of the role of protein dynamics in many enzymes. Here, we have used a combination of kinetic crystallography and detailed analysis of crystallographic protein ensembles to map the accessible conformational landscape of an insect carboxylesterase...[Show more]
Collections | ANU Research Publications |
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Date published: | 2016-06-07 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/107342 |
Source: | Structure |
DOI: | 10.1016/j.str.2016.04.009 |
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