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The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors

Smith, Hannah; Board, Mary; Pellagatti, Andrea; Turley, Helen; Boultwood, Jacqueline; Callaghan, Richard


Solid tumors contend with, and adapt to, a hostile micro-environment that includes limited availability of nutrient fuels and oxygen. The presence of hypoxia (O2 <5%) stabilizes the transcription factor Hif1 and results in numerous cellular adaptations including increased flux of glucose through glycolysis. Increasingly, more sophisticated analysis of tumor oxygenation has revealed large gradients of oxygen tension and significant regions under severe hypoxia (O2 ∼0.1%). The present...[Show more]

CollectionsANU Research Publications
Date published: 2016-08
Type: Journal article
Source: Journal of cellular biochemistry
DOI: 10.1002/jcb.25488


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