Novel role for heparan sulfate in thymic development of CD8⁺ T lymphocytes
The thymic stromal microenvironment is crucial for MHC-restricted positive and negative selection of T cells in the thymus to generate functional and self-tolerant alphabeta T cells. Our recent studies have provided new insights into this important process. We found that CD8beta molecules on CD4+CD8+ double positive (DP) thymocytes strongly interact with highly sulfated heparan sulfate (HS) carrying 6-O sulfate groups. Furthermore, we discovered that a HS...[Show more]
|Collections||Open Access Theses|
|Simon Davis Thesis 2016.pdf||45.58 MB||Adobe PDF|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.