Predicting vitamin D deficiency in older Australian adults
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Tran, Bich; Armstrong, Bruce K; McGeechan, Kevin; Ebeling, Peter R; English, Dallas R; Kimlin, Michael G; van der Pols, Jolieke, C; Venn, Alison; Gebski, Val; Whiteman, David C; Webb, Penelope M; Neale, Rachel E; Lucas, Robyn
Description
OBJECTIVE: There has been a dramatic increase in vitamin D testing in Australia in recent years, prompting calls for targeted testing. We sought to develop a model to identify people most at risk of vitamin D deficiency. Design and Participants: This is a cross-sectional study of 644 60- to 84-year-old participants, 95% of whom were Caucasian, who took part in a pilot randomized controlled trial of vitamin D supplementation. MEASUREMENTS: Baseline 25(OH)D was measured using the Diasorin...[Show more]
dc.contributor.author | Tran, Bich | |
---|---|---|
dc.contributor.author | Armstrong, Bruce K | |
dc.contributor.author | McGeechan, Kevin | |
dc.contributor.author | Ebeling, Peter R | |
dc.contributor.author | English, Dallas R | |
dc.contributor.author | Kimlin, Michael G | |
dc.contributor.author | van der Pols, Jolieke, C | |
dc.contributor.author | Venn, Alison | |
dc.contributor.author | Gebski, Val | |
dc.contributor.author | Whiteman, David C | |
dc.contributor.author | Webb, Penelope M | |
dc.contributor.author | Neale, Rachel E | |
dc.contributor.author | Lucas, Robyn | |
dc.date.accessioned | 2013-11-05T02:00:51Z | |
dc.date.available | 2013-11-05T02:00:51Z | |
dc.identifier.issn | 1365-2265 | |
dc.identifier.uri | http://hdl.handle.net/1885/10689 | |
dc.description.abstract | OBJECTIVE: There has been a dramatic increase in vitamin D testing in Australia in recent years, prompting calls for targeted testing. We sought to develop a model to identify people most at risk of vitamin D deficiency. Design and Participants: This is a cross-sectional study of 644 60- to 84-year-old participants, 95% of whom were Caucasian, who took part in a pilot randomized controlled trial of vitamin D supplementation. MEASUREMENTS: Baseline 25(OH)D was measured using the Diasorin Liaison platform. Vitamin D insufficiency and deficiency were defined using 50 and 25 nmol/l as cut-points, respectively. A questionnaire was used to obtain information on demographic characteristics and lifestyle factors. We used multivariate logistic regression to predict low vitamin D and calculated the net benefit of using the model compared with ‘test-all’ and ‘test-none’ strategies. RESULTS: The mean serum 25(OH)D was 42 (SD 14) nmol/1. Seventy-five per cent of participants were vitamin D insufficient and 10% deficient. Serum 25(OH)D was positively correlated with time outdoors, physical activity, vitamin D intake and ambient UVR, and inversely correlated with age,BMI and poor self-reported health status. These predictors explained approximately 21% of the variance in serum 25 (OH)D. The area under the ROC curve predicting vitamin D deficiency was 0 82. Net benefit for the prediction model was higher than that for the ‘test-all’ strategy at all probability thresholds and higher than the ‘test-none’ strategy for probabilities up to 60%. CONCLUSION: Our model could predict vitamin D deficiency with reasonable accuracy, but it needs to be validated in other populations before being implemented. | |
dc.description.sponsorship | NHMRC (National Health and Medical Research Council of Australia) | |
dc.format | 10 pages | |
dc.publisher | Wiley-Blackwell | |
dc.rights | http://www.sherpa.ac.uk/romeo/issn/0300-0664/ Author can archive pre-print (ie pre-refereeing); subject to Restrictions below, author can archive post-print (ie final draft post-refereeing) - restrictions - If signed CTA, only allowed with written permission and 0 to 24 months depending on journal and funding agency requirements; author cannot archive publisher's version/PDF. From Sherpa/Romeo as at 4/11/13. | |
dc.source | Clinical Endocrinology 79.5 (2013): 631-640 | |
dc.subject | circulating 25-hydroxyvitamin D | |
dc.subject | cancer risk | |
dc.subject | pancreatic-cancer | |
dc.subject | determinants | |
dc.subject | population | |
dc.subject | trial | |
dc.subject | models | |
dc.subject | US | |
dc.subject | men | |
dc.title | Predicting vitamin D deficiency in older Australian adults | |
dc.type | Journal article | |
local.description.notes | This research is funded by a grant - NHMRC | |
local.identifier.citationvolume | 79 | |
dcterms.dateAccepted | 2013-03-13 | |
dc.date.issued | 2013-11 | |
local.identifier.absfor | 111700 - PUBLIC HEALTH AND HEALTH SERVICES | |
local.identifier.ariespublication | f5625xPUB4434 | |
local.publisher.url | http://onlinelibrary.wiley.com/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Lucas, Robyn, ANU, National Centre for Epidemiology and Population Health | |
dc.relation | http://purl.org/au-research/grants/nhmrc/613655 | |
local.bibliographicCitation.issue | 5 | |
local.bibliographicCitation.startpage | 631 | |
local.bibliographicCitation.lastpage | 640 | |
local.identifier.doi | 10.1111/cen.12203 | |
dc.date.updated | 2015-12-11T08:57:08Z | |
local.identifier.scopusID | 2-s2.0-84885206070 | |
local.identifier.thomsonID | 000325249900006 | |
Collections | ANU Research Publications |
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