Computational studies of the E3 carboxylesterase from Lucilia cuprina
The Australian sheep blowfly, Lucilia cuprina, has evolved resistance to organophosphate insecticides via a single point mutation in a carboxylesterase (E3). In addition to their use as insecticides, organophosphates have been synthesised as chemical warfare agents, posing a threat to humans. Thus, an efficient organophosphate detoxification agent, such as E3, has potential value as a prophylactic that could break down organophosphates before they cause...[Show more]
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