Lifetime cigarette smoking is associated with striatal volume measures
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Das, Debjani; Cherbuin, Nicolas; Sachdev, Perminder Singh; Easteal, Simon; Anstey, Kaarin
Description
Nicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers’ brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers’. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors makes the striatum a potential target for nicotine. In addition, striatal nuclei are essential components of the reward/reinforcement pathway involved in addiction. The aim of this...[Show more]
dc.contributor.author | Das, Debjani | |
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dc.contributor.author | Cherbuin, Nicolas | |
dc.contributor.author | Sachdev, Perminder Singh | |
dc.contributor.author | Easteal, Simon | |
dc.contributor.author | Anstey, Kaarin | |
dc.date.accessioned | 2013-10-14T01:23:20Z | |
dc.date.available | 2013-10-14T01:23:20Z | |
dc.identifier.issn | 1355-6215 | |
dc.identifier.issn | 1369-1600 | |
dc.identifier.uri | http://hdl.handle.net/1885/10612 | |
dc.description.abstract | Nicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers’ brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers’. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors makes the striatum a potential target for nicotine. In addition, striatal nuclei are essential components of the reward/reinforcement pathway involved in addiction. The aim of this study was to explore the relationship between striatal nuclei (caudate, putamen and nucleus accumbens area) volumes and lifetime smoking in a large community-based sample of ‘young–old’ individuals. Brain volumes were measured using a semi-automated method in 315 participants aged 64–70 years who were selected from a larger randomly sampled cohort and who consented to a magnetic resonance imaging scan. Multiple regression analysis was used to assess the relationship between striatal volumes and cigarette smoking measures while controlling for age, sex, intracranial and total brain volumes and general physical and mental health measures. Greater lifetime use of cigarettes (measured in pack-years) was associated with smaller left nucleus accumbens area volume (P = 0.018) and larger left putamen volume (P = 0.025). Greater putaminal volume was also associated with a lower age at smoking initiation (P = 0.004). In this generally healthy cohort, lifetime use of cigarettes is significantly associated with striatal volume measures. These changes could indicate predisposing factors for nicotine addiction, or an effect of chronic nicotine exposure or a combination of both. | |
dc.description.sponsorship | NHMRC (National Health and Medical Research Council of Australia) | |
dc.format | 9 pages | |
dc.publisher | Wiley-Blackwell | |
dc.rights | http://authorservices.wiley.com/bauthor/lic_samples/eCTA-A_sample.pdf Author must sign a Copyright transfer Agreement . SUBMITTED VERSIONS: After publication of the final article, the right to self-archive on the Contributor’s … institution’s/employer’s institutional repository or archive. This right extends to both intranets and the Internet. The Contributor may not update the submission version or replace it with the published Contribution. The version posted must contain a legend as follows: This is the pre-peer reviewed version of the following article: FULL CITE, which has been published in final form at [Link to final article]. ACCEPTED VERSIONS: Re-use of the accepted and peer-reviewed (but not final) version of the Contribution is not permitted under this Agreement. There are separate arrangements with certain funding agencies governing reuse of this version. FINAL PUBLISHED VERSIONS : May be re-used for any publication authored or edited by the Contributor (excluding journal articles) where such re-used material constitutes less than half of the total material in such publication. In such case, any modifications should be accurately noted - from publisher web site (as at 24/9/13) | |
dc.source | Addiction Biology 17.4 (2010): 817-825 | |
dc.subject | brain volume | |
dc.subject | magnetic resonance imaging | |
dc.subject | nucleus accumbens | |
dc.subject | putamen | |
dc.subject | smoking | |
dc.title | Lifetime cigarette smoking is associated with striatal volume measures | |
dc.type | Journal article | |
local.description.notes | RGMS (Research Grants Management System) publication no. P001373089. The study was supported by NHMRC of Australia Unit Grant no. 973302, Program Grants no. 179805 and 350833, NHMRC project grant no. 157125. DD is funded by NHMRC Capacity Building Grant in Population Health Research 418020. NC is funded by NHMRC Research Fellowship no. 471501. KA is funded by NHMRC Research Fellowship no. 366756. This research was undertaken on the NCI National Facility in Canberra, Australia, which is supported by the Australian Commonwealth Government. | |
local.identifier.citationvolume | 17 | |
dc.date.issued | 2011-03-11 | |
local.identifier.absfor | 170100 - PSYCHOLOGY | |
local.identifier.ariespublication | u4020362xPUB198 | |
local.publisher.url | http://au.wiley.com/WileyCDA/Brand/id-35.html | |
local.type.status | Submitted Version | |
local.contributor.affiliation | Das, Debjani, ANU, John Curtin School of Medical Research | |
local.contributor.affiliation | Cherbuin, Nicolas, ANU, Centre for Mental Health Research | |
local.contributor.affiliation | Anstey, Kaarin J., ANU, Centre for Mental Health Research | |
local.contributor.affiliation | Sachdev, Perminder S., University of New South Wales, School of Psychiatry and Prince of Wales Hospital, Neuropsychiatric Institute | |
local.contributor.affiliation | Easteal, Simon, ANU, John Curtin School of Medical Research | |
dc.relation | http://purl.org/au-research/grants/nhmrc/418039 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1002160 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1002560 | |
local.bibliographicCitation.startpage | 817 | |
local.bibliographicCitation.lastpage | 825 | |
local.identifier.doi | 10.1111/j.1369-1600.2010.00301.x | |
local.identifier.absseo | 920502 - Health Related to Ageing | |
dc.date.updated | 2015-12-09T08:04:19Z | |
local.identifier.scopusID | 2-s2.0-84863465193 | |
local.identifier.thomsonID | 000305886200014 | |
Collections | ANU Research Publications |
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