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Lifetime cigarette smoking is associated with striatal volume measures

Das, Debjani; Cherbuin, Nicolas; Sachdev, Perminder Singh; Easteal, Simon; Anstey, Kaarin

Description

Nicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers’ brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers’. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors makes the striatum a potential target for nicotine. In addition, striatal nuclei are essential components of the reward/reinforcement pathway involved in addiction. The aim of this...[Show more]

dc.contributor.authorDas, Debjani
dc.contributor.authorCherbuin, Nicolas
dc.contributor.authorSachdev, Perminder Singh
dc.contributor.authorEasteal, Simon
dc.contributor.authorAnstey, Kaarin
dc.date.accessioned2013-10-14T01:23:20Z
dc.date.available2013-10-14T01:23:20Z
dc.identifier.issn1355-6215
dc.identifier.issn1369-1600
dc.identifier.urihttp://hdl.handle.net/1885/10612
dc.description.abstractNicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers’ brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers’. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors makes the striatum a potential target for nicotine. In addition, striatal nuclei are essential components of the reward/reinforcement pathway involved in addiction. The aim of this study was to explore the relationship between striatal nuclei (caudate, putamen and nucleus accumbens area) volumes and lifetime smoking in a large community-based sample of ‘young–old’ individuals. Brain volumes were measured using a semi-automated method in 315 participants aged 64–70 years who were selected from a larger randomly sampled cohort and who consented to a magnetic resonance imaging scan. Multiple regression analysis was used to assess the relationship between striatal volumes and cigarette smoking measures while controlling for age, sex, intracranial and total brain volumes and general physical and mental health measures. Greater lifetime use of cigarettes (measured in pack-years) was associated with smaller left nucleus accumbens area volume (P = 0.018) and larger left putamen volume (P = 0.025). Greater putaminal volume was also associated with a lower age at smoking initiation (P = 0.004). In this generally healthy cohort, lifetime use of cigarettes is significantly associated with striatal volume measures. These changes could indicate predisposing factors for nicotine addiction, or an effect of chronic nicotine exposure or a combination of both.
dc.description.sponsorshipNHMRC (National Health and Medical Research Council of Australia)
dc.format9 pages
dc.publisherWiley-Blackwell
dc.rightshttp://authorservices.wiley.com/bauthor/lic_samples/eCTA-A_sample.pdf Author must sign a Copyright transfer Agreement . SUBMITTED VERSIONS: After publication of the final article, the right to self-archive on the Contributor’s … institution’s/employer’s institutional repository or archive. This right extends to both intranets and the Internet. The Contributor may not update the submission version or replace it with the published Contribution. The version posted must contain a legend as follows: This is the pre-peer reviewed version of the following article: FULL CITE, which has been published in final form at [Link to final article]. ACCEPTED VERSIONS: Re-use of the accepted and peer-reviewed (but not final) version of the Contribution is not permitted under this Agreement. There are separate arrangements with certain funding agencies governing reuse of this version. FINAL PUBLISHED VERSIONS : May be re-used for any publication authored or edited by the Contributor (excluding journal articles) where such re-used material constitutes less than half of the total material in such publication. In such case, any modifications should be accurately noted - from publisher web site (as at 24/9/13)
dc.sourceAddiction Biology 17.4 (2010): 817-825
dc.subjectbrain volume
dc.subjectmagnetic resonance imaging
dc.subjectnucleus accumbens
dc.subjectputamen
dc.subjectsmoking
dc.titleLifetime cigarette smoking is associated with striatal volume measures
dc.typeJournal article
local.description.notesRGMS (Research Grants Management System) publication no. P001373089. The study was supported by NHMRC of Australia Unit Grant no. 973302, Program Grants no. 179805 and 350833, NHMRC project grant no. 157125. DD is funded by NHMRC Capacity Building Grant in Population Health Research 418020. NC is funded by NHMRC Research Fellowship no. 471501. KA is funded by NHMRC Research Fellowship no. 366756. This research was undertaken on the NCI National Facility in Canberra, Australia, which is supported by the Australian Commonwealth Government.
local.identifier.citationvolume17
dc.date.issued2011-03-11
local.identifier.absfor170100 - PSYCHOLOGY
local.identifier.ariespublicationu4020362xPUB198
local.publisher.urlhttp://au.wiley.com/WileyCDA/Brand/id-35.html
local.type.statusSubmitted Version
local.contributor.affiliationDas, Debjani, ANU, John Curtin School of Medical Research
local.contributor.affiliationCherbuin, Nicolas, ANU, Centre for Mental Health Research
local.contributor.affiliationAnstey, Kaarin J., ANU, Centre for Mental Health Research
local.contributor.affiliationSachdev, Perminder S., University of New South Wales, School of Psychiatry and Prince of Wales Hospital, Neuropsychiatric Institute
local.contributor.affiliationEasteal, Simon, ANU, John Curtin School of Medical Research
dc.relationhttp://purl.org/au-research/grants/nhmrc/418039
dc.relationhttp://purl.org/au-research/grants/nhmrc/1002160
dc.relationhttp://purl.org/au-research/grants/nhmrc/1002560
local.bibliographicCitation.startpage817
local.bibliographicCitation.lastpage825
local.identifier.doi10.1111/j.1369-1600.2010.00301.x
local.identifier.absseo920502 - Health Related to Ageing
dc.date.updated2015-12-09T08:04:19Z
local.identifier.scopusID2-s2.0-84863465193
local.identifier.thomsonID000305886200014
CollectionsANU Research Publications

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