Induction of long-lived humoral immunity to poxvirus infections
Smallpox eradication through the use of a live-virus vaccine is one of the most successful public health endeavors of modern medicine. Humoral immunity against the smallpox virus, characterized by neutralizing antiviral antibody response, is stable, lasts for decades, and is considered a valuable benchmark of the functional attributes of a good vaccine. Indeed, neutralizing antibody is the best correlate of long-term protective immunity for all the currently licensed clinically effective...[Show more]
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