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Hematopoiesis leading to a diversity of dendritic antigen-presenting cell types

Petvises, Sawang; O'Neill, Helen

Description

Hematopoietic stem cells (HSCs) undergo expansion and differentiation, giving rise to all terminally differentiated blood cells throughout life. HSCs are found in distinct anatomical sites during development, and in adults, hematopoiesis occurs predominantly on the luminal side of the bone cavity in bone marrow. Millions of newly formed blood cells are generated per second to accommodate the short half-life of hematopoietic cells. For this to happen, HSCs must sustain their self-renewal...[Show more]

dc.contributor.authorPetvises, Sawang
dc.contributor.authorO'Neill, Helen
dc.date.accessioned2013-09-24T01:56:30Z
dc.date.available2013-09-24T01:56:30Z
dc.identifier.issn0818-9641
dc.identifier.issn1440-1711
dc.identifier.urihttp://hdl.handle.net/1885/10536
dc.description.abstractHematopoietic stem cells (HSCs) undergo expansion and differentiation, giving rise to all terminally differentiated blood cells throughout life. HSCs are found in distinct anatomical sites during development, and in adults, hematopoiesis occurs predominantly on the luminal side of the bone cavity in bone marrow. Millions of newly formed blood cells are generated per second to accommodate the short half-life of hematopoietic cells. For this to happen, HSCs must sustain their self-renewal capacity as well as their capability to commit and differentiate toward multiple cell lineages. Development of the hematopoietic system is finely regulated as the animal ages, so that it does not become exhausted or misdirected. This review covers aspects of hematopoietic development from the embryonic period through adult life in relation to development of dendritic cells. It also considers a role for HSCs in extramedullary sites and their possible role in myelopoiesis, with formation of tissue-specific antigen-presenting cells.
dc.description.sponsorshipNHMRC (National Health and Medical Research Council of Australia)
dc.format27 pages
dc.publisherNature Publishing Group
dc.publisherAustralasian Society for Immunology
dc.rightshttp://www.sherpa.ac.uk/romeo/issn/0818-9641/ Author may archive pre-print. Author may archive post-print subject after 6 months embargo. On institutional repository. Author cannot archive publisher's version/PDF. Authors retain copyright. Published source must be acknowledged and DOI cited. Must link to publisher version - from SHERPA/RoMEO site (as at 18/9/13)
dc.sourceImmunology and Cell Biology 90.4 (2012): 372-378
dc.subjecthematopoiesis
dc.subjecthematopoietic stem cells
dc.subjectdendritic cells
dc.subjectmyelopoiesis
dc.titleHematopoiesis leading to a diversity of dendritic antigen-presenting cell types
dc.typeJournal article
local.description.notesThis research was funded through a grant. - NHMRC
local.identifier.citationvolumeOnline 12 July 2011
dcterms.dateAccepted2011-04-19
dc.date.issued2011-07-12
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationf2965xPUB2238
local.publisher.urlww.nature.com
local.type.statusAccepted Version
local.contributor.affiliationPetvises, Sawang, ANU, Research School of Biology, Division of Biomedical Sciences
local.contributor.affiliationO’Neill, Helen C., ANU, Research School of Biology, Division of Biomedical Sciences
dc.relationhttp://purl.org/au-research/grants/nhmrc/585443
local.bibliographicCitation.startpage1
local.bibliographicCitation.lastpage7
local.identifier.doi10.1038/icb.2011.47
local.identifier.absseo920108 - Immune System and Allergy
dc.date.updated2015-12-10T11:54:35Z
local.identifier.scopusID2-s2.0-84859947724
local.identifier.thomsonID000303002900003
CollectionsANU Research Publications

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