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Novel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor

Periasamy, Pravin; Tan, Jonathan K. H; O'Neill, Helen


The main DC subsets in murine spleen arise from BM-derived precursors. Recently, a novel APC type was described in spleen. To determine if spleen contains the progenitors of this subset, a stromal coculture system was used to assess candidate progenitors for their hematopoietic potential. Here, the progenitor of that subset is identified as a spleen endogenous Lin_c-kit lo hematopoietic progenitor and is most highly enriched among the Lin_c-kit(lo)CD34+ subset. Dendritic-like cells produced in...[Show more]

CollectionsANU Research Publications
Date published: 2012-10-25
Type: Journal article
Source: Journal of Leukocyte Biology 93.1 (2013): 63-9
DOI: 10.1189/jlb.0512260


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