Skip navigation
Skip navigation

Novel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor

Periasamy, Pravin; Tan, Jonathan K. H; O'Neill, Helen

Description

The main DC subsets in murine spleen arise from BM-derived precursors. Recently, a novel APC type was described in spleen. To determine if spleen contains the progenitors of this subset, a stromal coculture system was used to assess candidate progenitors for their hematopoietic potential. Here, the progenitor of that subset is identified as a spleen endogenous Lin_c-kit lo hematopoietic progenitor and is most highly enriched among the Lin_c-kit(lo)CD34+ subset. Dendritic-like cells produced in...[Show more]

CollectionsANU Research Publications
Date published: 2012-10-25
Type: Journal article
URI: http://hdl.handle.net/1885/10501
Source: Journal of Leukocyte Biology 93.1 (2013): 63-9
DOI: 10.1189/jlb.0512260

Download

There are no files associated with this item.


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator