Kinetics of antigen expression and epitope presentation during virus infection
Current knowledge about the dynamics of antigen presentation to T cells during viral infection is very poor despite being of fundamental importance to our understanding of anti-viral immunity. Here we use an advanced mass spectrometry method to simultaneously quantify the presentation of eight vaccinia virus peptide-MHC complexes (epitopes) on infected cells and the amounts of their source antigens at multiple times after infection. The results show a startling 1000-fold range in abundance as...[Show more]
|Collections||ANU Research Publications|
|Source:||PLoS Pathogens 9.1 (2013): e1003129|
|Croft_KineticsAntigen2013.pdf||1.14 MB||Adobe PDF|
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