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Kinetics of antigen expression and epitope presentation during virus infection

Croft, Nathan P.; Smith, Stewart A.; Wong, Yik Chun; Tan, Chor Teck; Dudek, Nadine L.; Flesch, Inge E. A.; Lin, Leon C. W.; Tscharke, David C.; Purcell, Anthony W.


Current knowledge about the dynamics of antigen presentation to T cells during viral infection is very poor despite being of fundamental importance to our understanding of anti-viral immunity. Here we use an advanced mass spectrometry method to simultaneously quantify the presentation of eight vaccinia virus peptide-MHC complexes (epitopes) on infected cells and the amounts of their source antigens at multiple times after infection. The results show a startling 1000-fold range in abundance as...[Show more]

CollectionsANU Research Publications
Date published: 2013-01-31
Type: Journal article
Source: PLoS Pathogens 9.1 (2013): e1003129
DOI: 10.1371/journal.ppat.1003129


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