Probing interactions of Vpu from HIV-1 with amiloride-based compounds
Viral ion channels or viroporins are short membrane proteins that participate in wide-ranging functions including virus replication and entry, assembly, and virus release. One such viroporin is the 81 amino acid residue Vpu protein derived from HIV-1. This protein consists of one transmembrane (TM) and two cytoplasmic helical domains, the former of which oligomerises to form cation-selective ion channels. In this study, we investigate the binding properties of amiloride compounds to Vpu...[Show more]
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|Source:||Biochimica et Biophysica Acta: Biomembranes|
|01_Rosenberg_Probing_interactions_of_Vpu_2016.pdf||883.17 kB||Adobe PDF||Request a copy|
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