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Probing interactions of Vpu from HIV-1 with amiloride-based compounds

Rosenberg, Matthew; Weaver, Llara; Casarotto, Marco

Description

Viral ion channels or viroporins are short membrane proteins that participate in wide-ranging functions including virus replication and entry, assembly, and virus release. One such viroporin is the 81 amino acid residue Vpu protein derived from HIV-1. This protein consists of one transmembrane (TM) and two cytoplasmic helical domains, the former of which oligomerises to form cation-selective ion channels. In this study, we investigate the binding properties of amiloride compounds to Vpu...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/103655
Source: Biochimica et Biophysica Acta: Biomembranes
DOI: 10.1016/j.bbamem.2015.12.028

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