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In vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc

Wang, Jun-Lang; Mukherjee, Shayanti; Nisbet, David; Birbilis, Nick; Chen, Xiaobo

Description

The in vitro degradation of magnesium (Mg) alloys containing low levels of strontium (Sr, 0.05, 0.1 and 0.2 wt%), with and without addition of zinc (Zn, 0.5 and 1.0 wt%), was studied for potential use in orthopaedics for fracture treatment. Alloying Mg with Sr was selected as a promising strategy to utilise the biological effect of Sr in inducing accelerated bone tissue growth. The influence of controlled alloying upon degradation rate was studied via electrochemical measurements and immersion...[Show more]

dc.contributor.authorWang, Jun-Lang
dc.contributor.authorMukherjee, Shayanti
dc.contributor.authorNisbet, David
dc.contributor.authorBirbilis, Nick
dc.contributor.authorChen, Xiaobo
dc.date.accessioned2016-06-14T23:20:56Z
dc.identifier.issn2050-750X
dc.identifier.urihttp://hdl.handle.net/1885/103624
dc.description.abstractThe in vitro degradation of magnesium (Mg) alloys containing low levels of strontium (Sr, 0.05, 0.1 and 0.2 wt%), with and without addition of zinc (Zn, 0.5 and 1.0 wt%), was studied for potential use in orthopaedics for fracture treatment. Alloying Mg with Sr was selected as a promising strategy to utilise the biological effect of Sr in inducing accelerated bone tissue growth. The influence of controlled alloying upon degradation rate was studied via electrochemical measurements and immersion tests in minimum essential medium (MEM). Immersion testing revealed a comparable degradation rate of the alloys tested herein, indicating no detrimental effect of Sr on degradation. Cytotoxicity experiments on primary mouse osteoblasts indicated good biocompatibility and enhanced proliferation of osteoblasts for all the tested Mg alloys. Potentiodynamic polarisation testing further confirmed that addition of low-levels of Sr had a minor influence on cathodic kinetics, with a slight inhibition of anodic kinetics. In contrast, the addition of Zn as a ternary element moderated both anodic and cathodic kinetics of Mg–Sr alloys.
dc.publisherRoyal Society of Chemistry
dc.sourceJournal of Materials Chemistry B
dc.titleIn vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume3
dc.date.issued2015
local.identifier.absfor030302 - Nanochemistry and Supramolecular Chemistry
local.identifier.absfor100404 - Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
local.identifier.ariespublicationU3488905xPUB8639
local.type.statusPublished Version
local.contributor.affiliationWang, Jun-Lang, Monash University
local.contributor.affiliationMukherjee, Shayanti, College of Engineering and Computer Science, ANU
local.contributor.affiliationNisbet, David, College of Engineering and Computer Science, ANU
local.contributor.affiliationBirbilis, Nick, Monash University
local.contributor.affiliationChen, Xiaobo, Monash University
local.description.embargo2037-12-31
local.bibliographicCitation.startpage8874
local.bibliographicCitation.lastpage8883
local.identifier.doi10.1039/c5tb01516b
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
dc.date.updated2016-06-14T08:54:20Z
local.identifier.scopusID2-s2.0-84946944803
CollectionsANU Research Publications

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