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The N-terminal region of chromodomain helicase DNA-binding protein 4 (CHD4) is essential for activity and contains a high mobility group (HMG) box-like-domain that can bind poly(ADP-ribose)

Silva, Ana; Ryan, Daniel; Galanty, Yaron; Low, Jason; Vandevenne, Marylene; Jackson, Stephen; Mackay, Joel P.


Chromodomain Helicase DNA-binding protein 4 (CHD4) is a chromatin-remodeling enzyme that has been reported to regulate DNA-damage responses through its N-terminal region in a poly(ADP-ribose) polymerase-dependent manner. We have identified and determined the structure of a stable domain (CHD4-N) in this N-terminal region. The-fold consists of a four- -helix bundle with structural similarity to the high mobility group box, a domain that is well known as a DNA binding module. We show that the...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M115.683227


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