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Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study

Thibeau, Sherilyn; McFall, G. Peggy; Wiebe, Sandra; Dixon, Roger A.; Anstey, Kaarin


Objective: Everyday physical activity (EPA) is an important modifiable contributor to age-related variability in executive functioning (EF). However, its role may be moderated by nonmodifiable genetic factors. We tested independent and interactive effects of brain-derived neurotrophic factor (BDNF rs6265) and insulin degrading enzyme (IDE rs6583817) on EF and EPA–EF relationships. Method: The sample consisted of genotyped older adults (N = 577; M age = 70.47 years) over 3 waves (∼9 years) of...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Neuropsychology
DOI: 10.1037/neu0000217


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