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Hypertension, antihypertensive treatment and cancer incidence and mortality: A pooled collaborative analysis of 12 Australian and New Zealand cohorts

Harding, Jessica; Sooriyakumaran, Manoshayini; Adams, Robert; Balkau, Beverley; Brennan-Olsen, Sharon; Briffa, Tom G; Davis, Timothy; Dobson, Annette; Giles, Graham G; Grant, Janet; Huxley, Rachel; Knuiman, Matthew; Luszcz, Mary A; Mitchell, Paul; Pasco, Julie A.; Reid, Christopher; Simmons, David; Simons, Leon; Taylor, Anne; Tonkin, Andrew; Woodward, Mark; Shaw, Jonathan; Magliano, Dianna; Anstey, Kaarin

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Background: Observational studies examining associations between hypertension and cancer are inconsistent. We explored the association of hypertension, graded hypertension and antihypertensive treatment with cancer incidence and mortality. Method: Eighty-six thousand five hundred and ninety-three participants from the Australian and New Zealand Diabetes and Cancer Collaboration were linked to the National Death Index and Australian Cancer Database. Cox proportional hazards models estimated...[Show more]

dc.contributor.authorHarding, Jessica
dc.contributor.authorSooriyakumaran, Manoshayini
dc.contributor.authorAdams, Robert
dc.contributor.authorBalkau, Beverley
dc.contributor.authorBrennan-Olsen, Sharon
dc.contributor.authorBriffa, Tom G
dc.contributor.authorDavis, Timothy
dc.contributor.authorDobson, Annette
dc.contributor.authorGiles, Graham G
dc.contributor.authorGrant, Janet
dc.contributor.authorHuxley, Rachel
dc.contributor.authorKnuiman, Matthew
dc.contributor.authorLuszcz, Mary A
dc.contributor.authorMitchell, Paul
dc.contributor.authorPasco, Julie A.
dc.contributor.authorReid, Christopher
dc.contributor.authorSimmons, David
dc.contributor.authorSimons, Leon
dc.contributor.authorTaylor, Anne
dc.contributor.authorTonkin, Andrew
dc.contributor.authorWoodward, Mark
dc.contributor.authorShaw, Jonathan
dc.contributor.authorMagliano, Dianna
dc.contributor.authorAnstey, Kaarin
dc.date.accessioned2016-06-14T23:20:42Z
dc.identifier.issn0263-6352
dc.identifier.urihttp://hdl.handle.net/1885/103506
dc.description.abstractBackground: Observational studies examining associations between hypertension and cancer are inconsistent. We explored the association of hypertension, graded hypertension and antihypertensive treatment with cancer incidence and mortality. Method: Eighty-six thousand five hundred and ninety-three participants from the Australian and New Zealand Diabetes and Cancer Collaboration were linked to the National Death Index and Australian Cancer Database. Cox proportional hazards models estimated hazard ratios and 95% confidence intervals (95% CI) for the association of treated and untreated hypertension with cancer incidence and mortality. Results: Over a median follow-up of 15.1 years, 12 070 incident and 4350 fatal cancers were identified. Untreated and treated hypertension, compared with normotension, were associated with an increased risk for cancer incidence [hazard ratio 1.06, 95% CI (1.00–1.11) and 1.09 (1.02– 1.16) respectively], and cancer mortality (1.07, 0.98–1.18) and (1.15, 1.03–1.28), respectively. When compared with untreated hypertension, treated hypertension did not have a significantly greater risk for cancer incidence (1.03, 0.97–1.10) or mortality (1.07, 0.97–1.19). A significant dose–response relationship was observed between graded hypertension and cancer incidence and mortality; Ptrend¼ 0.053 and Ptrend¼ 0.001, respectively. When stratified by treatment status, these relationships remained significant in untreated, but not in treated, hypertension. Conclusion: Hypertension, both treated and untreated, is associated with a modest increased risk for cancer incidence and mortality. Similar risks in treated and untreated hypertension suggest that the increased cancer risk is not explained by the use of antihypertensive treatment.
dc.publisherLippincott Williams & Wilkins
dc.sourceJournal of Hypertension
dc.titleHypertension, antihypertensive treatment and cancer incidence and mortality: A pooled collaborative analysis of 12 Australian and New Zealand cohorts
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume34
dc.date.issued2016
local.identifier.absfor110300 - CLINICAL SCIENCES
local.identifier.absfor111700 - PUBLIC HEALTH AND HEALTH SERVICES
local.identifier.absfor170100 - PSYCHOLOGY
local.identifier.ariespublicationU3488905xPUB8286
local.type.statusPublished Version
local.contributor.affiliationHarding, Jessica, Monash University
local.contributor.affiliationSooriyakumaran, Manoshayini, Monash University
local.contributor.affiliationAnstey, Kaarin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationAdams, Robert, School of Medicine, University of Adelaide
local.contributor.affiliationBalkau, Beverley, INSERM
local.contributor.affiliationBrennan-Olsen, Sharon, Deakin University
local.contributor.affiliationBriffa, Tom G, School of Population Health
local.contributor.affiliationDavis, Timothy, University of Western Australia
local.contributor.affiliationDobson, Annette, University of Queensland
local.contributor.affiliationGiles, Graham G, Cancer Council Victoria
local.contributor.affiliationGrant, Janet, University of Adelaide
local.contributor.affiliationHuxley, Rachel, University of Queensland
local.contributor.affiliationKnuiman, Matthew, University of Western Australia
local.contributor.affiliationLuszcz, Mary A, Flinders University
local.contributor.affiliationMitchell, Paul, University of Sydney
local.contributor.affiliationPasco, Julie A., University of Melbourne
local.contributor.affiliationReid, Christopher, Curtin University
local.contributor.affiliationSimmons, David, University of Western Sydney
local.contributor.affiliationSimons, Leon, University of New South Wales (St Vincent's Clinical School)
local.contributor.affiliationTaylor, Anne, University of Adelaide
local.contributor.affiliationTonkin, Andrew, Monash University
local.contributor.affiliationWoodward, Mark, The George Institute for Global Health
local.contributor.affiliationShaw, Jonathan, Baker IDI Heart and Diabetes Institute
local.contributor.affiliationMagliano, Dianna, Baker IDI Heart and Diabetes Institute
local.description.embargo2037-12-31
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage149
local.bibliographicCitation.lastpage155
local.identifier.doi10.1097/HJH.0000000000000770
dc.date.updated2016-06-14T08:51:40Z
local.identifier.scopusID2-s2.0-84950141477
CollectionsANU Research Publications

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