Dynamics of Fluorescent Dyes Attached to G-Quadruplex DNA and their Effect on FRET Experiments
FRET spectroscopy is a promising approach for investigating the dynamics of G-quadruplex DNA folds and improving the targeting of G-quadruplexes by potential anticancer compounds. To better interpret such experiments, classical and replica-exchange molecular dynamics simulations and fluorescence-lifetime measurements are used to understand the behavior of a range of Cy3-based dyes attached to the 3′ end of G-quadruplex DNA. The simulations revealed that the dyes interact extensively with the...[Show more]
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