Skip navigation
Skip navigation

Dynamics of Fluorescent Dyes Attached to G-Quadruplex DNA and their Effect on FRET Experiments

Søndergaard, Siri; Aznauryan, Mikayel; Haustrup, Emil K.; Schiøtt, Birgit; Birkedal, Victoria; Corry, Ben

Description

FRET spectroscopy is a promising approach for investigating the dynamics of G-quadruplex DNA folds and improving the targeting of G-quadruplexes by potential anticancer compounds. To better interpret such experiments, classical and replica-exchange molecular dynamics simulations and fluorescence-lifetime measurements are used to understand the behavior of a range of Cy3-based dyes attached to the 3′ end of G-quadruplex DNA. The simulations revealed that the dyes interact extensively with the...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/103429
Source: ChemPhysChem
DOI: 10.1002/cphc.201500271

Download

File Description SizeFormat Image
01_S%C3%B8ndergaard_Dynamics_of_Fluorescent_Dyes_2015.pdf3.74 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator