Nucleosome-specific, time-dependent changes in histone modifications during activation of the early growth response 1 (Egr1) gene
Histone post-translational modifications and nucleosome remodeling are coordinate eventsinvolvedin eukaryotic transcriptional regulation. There are relatively few data on the time course with which these events occurinindividual nucleosomes. As a contribution to fill this gap,we first describe the natureand time course of structural changes in the nucleosomes 2, 1, and 1 of the murine Egr1 gene upon induction. To initiate the transient activation of the gene, we used the stimulation ofMLP29...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Biological Chemistry|
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