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Nucleosome-specific, time-dependent changes in histone modifications during activation of the early growth response 1 (Egr1) gene

Riffo-Campos, Angela L.; Castillo, Josefa; Tur, Gema; Gonzalez, Paula; Georgieva, Elena I; Rodriguez, Jose L; Lopez-Rodas, Gerardo; Rodrigo, Isabel; Franco, Luis

Description

Histone post-translational modifications and nucleosome remodeling are coordinate eventsinvolvedin eukaryotic transcriptional regulation. There are relatively few data on the time course with which these events occurinindividual nucleosomes. As a contribution to fill this gap,we first describe the natureand time course of structural changes in the nucleosomes 2, 1, and 1 of the murine Egr1 gene upon induction. To initiate the transient activation of the gene, we used the stimulation ofMLP29...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/103420
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M114.579292

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