Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in nondemented older adults
Introduction: We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease genetic risk score (GRS) on neurocognitive speed performance and change in nondemented older adults. Methods: In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline median age = 69.0) followed over 9 years. The GRS was compiled using the cumulative...[Show more]
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|Source:||Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring|
|01_McFall_Alzheimer%27s_genetic_risk_2015.pdf||413.87 kB||Adobe PDF||Request a copy|
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