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Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in nondemented older adults

McFall, G. Peggy; Wiebe, Sandra; Vergote, David; Dixon, Roger A.; Anstey, Kaarin


Introduction: We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease genetic risk score (GRS) on neurocognitive speed performance and change in nondemented older adults. Methods: In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline median age = 69.0) followed over 9 years. The GRS was compiled using the cumulative...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
DOI: 10.1016/j.dadm.2015.08.002
Access Rights: Open Access


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