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Unexpected dependence of RyR1 splice variant expression in human lower limb muscles on fiber-type composition

Willemse, Hermia; Theodoratos, Angelo; Smith, Paul; Dulhunty, Angela


The skeletal muscle ryanodine receptor Ca2+ release channel (RyR1), essential for excitation-contraction (EC) coupling, demonstrates a known developmentally regulated alternative splicing in the ASI region. We now find unexpectedly that the expression of the splice variants is closely related to fiber type in adult human lower limb muscles. We examined the distribution of myosin heavy chain isoforms and ASI splice variants in gluteus minimus, gluteus medius and vastus medialis from patients...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Pflugers Archives European Journal of Physiology
DOI: 10.1007/s00424-015-1738-9


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