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Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

Kirian, Richard; Awel, Salah; Eckerskorn, Niko; Fleckenstein , Holger; Wiedorn, Max; Adriano, Jean-Marc; Bajt, S; Barthelmess, M; Bean, R; Beyerlein, K. R.; Chavasit, Visith; Chavas, L. M. G.; Domaracky, M; Heymann, M; Horke, D. A.; Knoska, J; Metz, M.; Morgan, A; Oberthuer, D; Roth, N; Sato, T; Xavier, P. L.; Yefanov, O; Rode, Andrei V; Kupper, Jochen; Chapman, Henry

Description

A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a...[Show more]

dc.contributor.authorKirian, Richard
dc.contributor.authorAwel, Salah
dc.contributor.authorEckerskorn, Niko
dc.contributor.authorFleckenstein , Holger
dc.contributor.authorWiedorn, Max
dc.contributor.authorAdriano, Jean-Marc
dc.contributor.authorBajt, S
dc.contributor.authorBarthelmess, M
dc.contributor.authorBean, R
dc.contributor.authorBeyerlein, K. R.
dc.contributor.authorChavasit, Visith
dc.contributor.authorChavas, L. M. G.
dc.contributor.authorDomaracky, M
dc.contributor.authorHeymann, M
dc.contributor.authorHorke, D. A.
dc.contributor.authorKnoska, J
dc.contributor.authorMetz, M.
dc.contributor.authorMorgan, A
dc.contributor.authorOberthuer, D
dc.contributor.authorRoth, N
dc.contributor.authorSato, T
dc.contributor.authorXavier, P. L.
dc.contributor.authorYefanov, O
dc.contributor.authorRode, Andrei V
dc.contributor.authorKupper, Jochen
dc.contributor.authorChapman, Henry
dc.date.accessioned2016-06-14T23:20:18Z
dc.identifier.issn2329-7778
dc.identifier.urihttp://hdl.handle.net/1885/103308
dc.description.abstractA major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.
dc.publisherAIP Publishing LLC
dc.sourceStructural Dynamics
dc.titleSimple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume2
dc.date.issued2015
local.identifier.absfor020500 - OPTICAL PHYSICS
local.identifier.ariespublicationU3488905xPUB6439
local.type.statusPublished Version
local.contributor.affiliationKirian, Richard, Center for Free-Electron Laser Science
local.contributor.affiliationAwel, Salah, 4Center for Free-Electron Laser Science, DESY
local.contributor.affiliationEckerskorn, Niko, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationFleckenstein , Holger, State University of New York
local.contributor.affiliationWiedorn, Max, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationAdriano, Jean-Marc, Laboratoire de Bioe´ nerge´tique et Biotechnolog
local.contributor.affiliationBajt, S, Deutsches Elektronen-Synchrotron DESY
local.contributor.affiliationBarthelmess, M, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationBean, R, European XFEL GmbH
local.contributor.affiliationBeyerlein, K. R., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationChavasit, Visith, Mahidol University
local.contributor.affiliationChavas, L. M. G., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationDomaracky, M, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationHeymann, M, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationHorke, D. A., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationKnoska, J, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationMetz, M., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationMorgan, A, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationOberthuer, D, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationRoth, N, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationSato, T, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationXavier, P. L., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationYefanov, O, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationRode, Andrei V, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKupper, Jochen, Center for Free-Electron Laser Science,
local.contributor.affiliationChapman, Henry, University of Hamburg / DESY
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.identifier.doi10.1063/1.4922648
local.identifier.absseo970102 - Expanding Knowledge in the Physical Sciences
dc.date.updated2016-06-14T08:47:48Z
local.identifier.scopusID2-s2.0-84944080576
CollectionsANU Research Publications

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