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Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

Kirian, Richard; Awel, Salah; Eckerskorn, Niko; Fleckenstein, Holger; Wiedorn, Max; Adriano, Jean-Marc; Bajt, S.; Barthelmess, M.; Bean, R.; Beyerlein, K. R.; Chavasit, Visith; Chavas, L. M. G.; Domaracky, M.; Heymann, M.; Horke, D. A.; Knoska, J.; Metz, M.; Morgan, A.; Oberthuer, D.; Roth, N.; Sato, T.; Xavier, P. L.; Yefanov, O.; Rode, Andrei V.; Kupper, Jochen; Chapman, Henry

Description

A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a...[Show more]

dc.contributor.authorKirian, Richard
dc.contributor.authorAwel, Salah
dc.contributor.authorEckerskorn, Niko
dc.contributor.authorFleckenstein, Holger
dc.contributor.authorWiedorn, Max
dc.contributor.authorAdriano, Jean-Marc
dc.contributor.authorBajt, S.
dc.contributor.authorBarthelmess, M.
dc.contributor.authorBean, R.
dc.contributor.authorBeyerlein, K. R.
dc.contributor.authorChavasit, Visith
dc.contributor.authorChavas, L. M. G.
dc.contributor.authorDomaracky, M.
dc.contributor.authorHeymann, M.
dc.contributor.authorHorke, D. A.
dc.contributor.authorKnoska, J.
dc.contributor.authorMetz, M.
dc.contributor.authorMorgan, A.
dc.contributor.authorOberthuer, D.
dc.contributor.authorRoth, N.
dc.contributor.authorSato, T.
dc.contributor.authorXavier, P. L.
dc.contributor.authorYefanov, O.
dc.contributor.authorRode, Andrei V.
dc.contributor.authorKupper, Jochen
dc.contributor.authorChapman, Henry
dc.date.accessioned2016-06-14T23:20:18Z
dc.identifier.issn2329-7778
dc.identifier.urihttp://hdl.handle.net/1885/103308
dc.description.abstractA major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.
dc.publisherAIP Publishing LLC
dc.sourceStructural Dynamics
dc.titleSimple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume2
dc.date.issued2015
local.identifier.absfor020500 - OPTICAL PHYSICS
local.identifier.ariespublicationU3488905xPUB6439
local.type.statusPublished Version
local.contributor.affiliationKirian, Richard, Center for Free-Electron Laser Science
local.contributor.affiliationAwel, Salah, 4Center for Free-Electron Laser Science, DESY
local.contributor.affiliationEckerskorn, Niko, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationFleckenstein , Holger, State University of New York
local.contributor.affiliationWiedorn, Max, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationAdriano, Jean-Marc, Laboratoire de Bioe´ nerge´tique et Biotechnolog
local.contributor.affiliationBajt, S, Deutsches Elektronen-Synchrotron DESY
local.contributor.affiliationBarthelmess, M, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationBean, R, European XFEL GmbH
local.contributor.affiliationBeyerlein, K. R., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationChavasit, Visith, Mahidol University
local.contributor.affiliationChavas, L. M. G., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationDomaracky, M, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationHeymann, M, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationHorke, D. A., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationKnoska, J, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationMetz, M., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationMorgan, A, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationOberthuer, D, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationRoth, N, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationSato, T, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationXavier, P. L., Center for Free-Electron Laser Science, DESY
local.contributor.affiliationYefanov, O, Center for Free-Electron Laser Science, DESY
local.contributor.affiliationRode, Andrei V, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKupper, Jochen, Center for Free-Electron Laser Science,
local.contributor.affiliationChapman, Henry, University of Hamburg / DESY
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.identifier.doi10.1063/1.4922648
local.identifier.absseo970102 - Expanding Knowledge in the Physical Sciences
dc.date.updated2016-06-14T08:47:48Z
local.identifier.scopusID2-s2.0-84944080576
CollectionsANU Research Publications

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