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Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin

Fairweather, Stephen; Broer, Angelika; Subramanian, Nandhitha; Tumer, Emrah; Cheng, Qi; Schmoll, Dieter; O'Mara, Megan; Broer, Stefan

Description

Many solute carrier 6 (SLC6) family transporters require ancillary subunits to modify their expression and activity. The main apical membrane neutral amino acid transporters in mouse intestine and kidney, B0AT1 and B0AT3, require the ancillary protein collectrin or ACE2 for plasma membrane expression. Expression and activity of SLC6 neurotransmitter transporters are modulated by interaction with syntaxin 1A. Utilizing monocarboxylate-B0AT1/3 fusion constructs, we discovered that collectrin is...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/103297
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M115.648519

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