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Analytical bias in the measurement of serum 25-hydroxyVitamin D concentrations impairs assessment of Vitamin D status in clinical and research settings

Black, Lucinda; Anderson, Denise; Clarke, Michael; Ponsonby, Anne-Louise; Chapman, C; Coulthard, Alan; Dear, Keith; Dwyer, Terry; Kilpatrick, Trevor J; Lucas, Robyn

Description

Measured serum 25-hydroxyvitamin D concentrations vary depending on the type of assay used and the specific laboratory undertaking the analysis, impairing the accurate assessment of vitamin D status. We investigated differences in serum 25-hydroxyvitamin D concentrations measured at three laboratories (laboratories A and B using an assay based on liquid chroma-tography-tandem mass spectrometry and laboratory C using a DiaSorin Liaison assay), against a laboratory using an assay based on liquid...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/103293
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0135478

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