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Cyclic Phosphine Oxides and Phosphinamides from Di-Grignard Reagents and Phosphonic Dichlorides: Modular Access to Annulated Phospholanes

Gregson, Aaron M.; Wales, Steven M; Bailey, Stephen J.; Willis, Anthony; Keller, Paul


The reaction between 1,4-di-Grignard reagents and phosphonous(III) dichlorides is a classical method for the direct synthesis of phospholanes. Reported here is an extension of this approach to the preparation of value-added, annulated phospholane oxides, achieved through the combination of carbocyclic-fused di-Grignard reagents and readily available phosphonic(V) dichlorides. The procedure is amenable to (benz)annulation at both the 2,3- and 3,4-positions of the phospholane ring, and a variety...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b01476


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