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GWAS-identified risk variants for major depressive disorder: Preliminary support for an association with late-life depressive symptoms and brain structural alterations

Ryan, Joanne; Artero, Sylvaine; Carrière, Isabelle; Maller, Jerome; Meslin, Chantal; Ritchie, Karen; Ancelin, Marie-Laure


A number of genome-wide association studies (GWAS) have investigated risk factors for major depressive disorder (MDD), however there has been little attempt to replicate these findings in population-based studies of depressive symptoms. Variants within three genes, BICC1, PCLO and GRM7 were selected for replication in our study based on the following criteria: they were identified in a prior MDD GWAS study; a subsequent study found evidence that they influenced depression risk; and there is a...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: European Neuropsychopharmacology
DOI: 10.1016/j.euroneuro.2015.08.022


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