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Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy

Deplazes, Evelyne; Begg, Stephanie; van Wonderen, Jessica H.; Campbell, Rebecca; Kobe, Bostjan; Paton, James C.; MacMillan, Fraser; McDevitt, Christopher A; O'Mara, Megan


Prokaryotic metal-ion receptor proteins, or solute-binding proteins, facilitate the acquisition of metal ions from the extracellular environment. Pneumococcal surface antigen A (PsaA) is the primary Mn2+-recruiting protein of the human pathogen Streptococcus pneumoniae and is essential for its in vivo colonization and virulence. The recently reported high-resolution structures of metal-free and metal-bound PsaA have provided the first insights into the mechanism of PsaA-facilitated metal...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Biophysical Chemistry
DOI: 10.1016/j.bpc.2015.08.004


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