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Deamidation of N76 in human γS-crystallin promotes dimer formation

Ray, Nicholas; Hall, Damien; Carver, John


Background: Cataract formation is often attributed to the build-up of post-translational modifications in the crystallin proteins of the eye lens. One such modification, the deamidation of N76 in human γS-crystallin to D76, is highly correlated with age-related cataract (Hooi et al. Invest. Ophthalmol. Vis. Sci. 53 (2012) 3554-3561). In the current work, this modification has been extensively characterised in vitro.. Methods: Biophysical characterisation was performed on wild type and N76D...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Biochimica et Biophysica Acta - General Subjects
DOI: 10.1016/j.bbagen.2015.08.015


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