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Amyloid Beta: One of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

Clark, Ian A; Vissel, Bryce

Description

This review concerns how the primary inflammation preceding the generation of certain key damage-associated molecular patterns (DAMPs) arises in Alzheimer's disease (AD). In doing so, it places soluble amyloid β (Aβ), a protein hitherto considered as a primary initiator of AD, in a novel perspective. We note here that increased soluble Aβ is one of the proinflammatory cytokine-induced DAMPs recognized by at least one of the toll-like receptors on and in various cell types. Moreover, Aβ is best...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/103177
Source: British Journal of Pharmacology
DOI: 10.1111/bph.13181

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