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Tuning the mechanical and morphological properties of self-assembled peptide hydrogels via control over the gelation mechanism through regulation of ionic strength and the rate of pH change

Li, Rui; Horgan, Conor; Long, Benjamin; Rodriguez, Alexandra; Mather, Lauren; Barrow, Colin J; Nisbet, David; Williams, Richard J


Hydrogels formed by the self-assembly of peptides are promising biomaterials. The bioactive and biocompatible molecule Fmoc-FRGDF has been shown to be an efficient hydrogelator via a π-β self-assembly mechanism. Herein, we show that the mechanical properties and morphology of Fmoc-FRGDF hydrogels can be effectively and easily manipulated by tuning both the final ionic strength and the rate of pH change. The increase of ionic strength, and consequent increase in rate of gelation and stiffness,...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: RSC Advances
DOI: 10.1039/c4ra13266a


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