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Low seroprevalence of murray valley encephalitis and kunjin viruses in an opportunistic serosurvey, Victoria 2011

Williams, Stephanie; Richards, Jack S; Faddy, Helen; Leydon, Jennie A; Moran, Rodney; Nicholson, Suellen; Perry, Faye; Paskin, Roger; Catton, M C; Lester, Rosemary; Mackenzie, John S

Description

Objective: To assess evidence of recent and past exposure to Murray Valley encephalitis virus (MVEV) and West Nile clade Kunjin virus (KUNV) in residents of the Murray Valley, Victoria, during a period of demonstrated activity of both viruses in early 2011. Methods: A cross-sectional serosurvey using two convenience samples: stored serum specimens from a diagnostic laboratory in Mildura and blood donors from the Murray Valley region. Specimens were collected between April and July 2011. The...[Show more]

dc.contributor.authorWilliams, Stephanie
dc.contributor.authorRichards, Jack S
dc.contributor.authorFaddy, Helen
dc.contributor.authorLeydon, Jennie A
dc.contributor.authorMoran, Rodney
dc.contributor.authorNicholson, Suellen
dc.contributor.authorPerry, Faye
dc.contributor.authorPaskin, Roger
dc.contributor.authorCatton, M C
dc.contributor.authorLester, Rosemary
dc.contributor.authorMackenzie, John S
dc.date.accessioned2016-06-14T23:19:42Z
dc.identifier.issn1326-0200
dc.identifier.urihttp://hdl.handle.net/1885/103018
dc.description.abstractObjective: To assess evidence of recent and past exposure to Murray Valley encephalitis virus (MVEV) and West Nile clade Kunjin virus (KUNV) in residents of the Murray Valley, Victoria, during a period of demonstrated activity of both viruses in early 2011. Methods: A cross-sectional serosurvey using two convenience samples: stored serum specimens from a diagnostic laboratory in Mildura and blood donors from the Murray Valley region. Specimens were collected between April and July 2011. The main outcome measure was total antibody (IgM and IgG) reactivity against MVEV and KUNV measured using an enzyme immunoassay and defined as inhibiting binding of monoclonal antibodies by >50%, when compared to negative controls. Evidence of recent exposure was measured by the presence of MVEV and KUNV IgM detected by immunofluorescence. Results: Of 1,115 specimens, 24 (2.2%, 95% CI 1.3–3.0%) were positive for MVEV total antibody, and all were negative for MVEV IgM. Of 1,116 specimens, 34 (3.1%, 95% CI 2.0–4.0%) were positive for KUNV total antibody, and 3 (0.27%) were KUNV IgM positive. Total antibody seroprevalence for both viruses was higher in residents born before 1974. Conclusions: Despite widespread MVEV and KUNV activity in early 2011, this study found that seroprevalence of antibodies to both viruses was low (<5%) and little evidence of recent exposure. Implications: Our findings suggest both viruses remain epizootic in the region and local residents remain potentially susceptible to future outbreaks.
dc.publisherPublic Health Association of Australia
dc.sourceAustralian and New Zealand Journal of Public Health
dc.titleLow seroprevalence of murray valley encephalitis and kunjin viruses in an opportunistic serosurvey, Victoria 2011
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume37
dc.date.issued2013
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationU3488905xPUB13634
local.type.statusPublished Version
local.contributor.affiliationWilliams, Stephanie, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRichards, Jack S, Burnet Institute
local.contributor.affiliationFaddy, Helen, Australian Red Cross Blood Service
local.contributor.affiliationLeydon, Jennie A, Victorian Infectious Diseases Reference Laboratory
local.contributor.affiliationMoran, Rodney, VIC Department of Health
local.contributor.affiliationNicholson, Suellen, Victorian Infectious Disease Reference Laboratory
local.contributor.affiliationPerry, Faye, Barratt and Smith Pathology
local.contributor.affiliationPaskin, Roger, Victorian Department of Environment and Primary Industries
local.contributor.affiliationCatton, M C, Victorian Infectious Diseases Reference Laboratory
local.contributor.affiliationLester, Rosemary, VIC Department of Human Services
local.contributor.affiliationMackenzie, John S, Curtin University of Technology
local.description.embargo2037-12-31
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage427
local.bibliographicCitation.lastpage433
local.identifier.doi10.1111/1753-6405.12113
dc.date.updated2016-06-14T08:42:09Z
local.identifier.scopusID2-s2.0-84885466366
CollectionsANU Research Publications

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