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PR55a-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

Gilan, Omer; Diesch, Jeannine; Amalia, Marcia; Jastrzebski, Katarzyna; Chueh, A C; Verrills, N M; Pearson, Richard B; Mariadason, J M; Tulchinsky, Eugene; Hannan, Ross; Dhillon, Amardeep S.


The proto-oncogene c-Jun is a component of activator protein-1 (AP-1) transcription factor complexes that regulates processes essential for embryonic development, tissue homeostasis and malignant transformation. Induction of gene expression by c-Jun involves stimulation of its transactivation ability and upregulation of DNA binding capacity. While it is well established that the former requires JNK-mediated phosphorylation of S63/S73, the mechanism(s) through which binding of c-Jun to its...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Oncogene
DOI: 10.1038/onc.2014.26


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