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Identification of chromatin accessibility domains in human breast cancer stem cells

Hardy, Kristine; Wu, Fan; Tu, W.; Zafar, Anjum; Boulding, Tara; McCuaig, Robert; Sutton, C. R.; Theodoratos, Angelo; Rao, Sudha


Epithelial-to-mesenchymal transition (EMT) is physiological in embryogenesis and wound healing but also associated with the formation of cancer stem cells (CSCs). Many EMT signaling pathways are implicated in CSC formation, but the precise underlying mechanisms of CSC formation remain elusive. We have previously demonstrated that PKC is critical for EMT induction and CSC formation in inducible breast EMT/CSC models. Here, we used formaldehyde-assisted isolation of regulatory elements-sequencing...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Nucleus
DOI: 10.1080/19491034.2016.1150392


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