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Effects of exposure to Bovine viral diarrhoea virus 1 on risk of bovine respiratory disease in Australian feedlot cattle

Hay, K E; Ambrose, R C K; Morton, J M; Horwood, P F; Gravel, J L; Waldron, S; Commins, M A; Fowler, E V; Barnes, Tamsin S; Mahony, T J; Clements, Archie

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Viruses play a key role in the complex aetiology of bovine respiratory disease (BRD). Bovine viral diarrhoea virus 1 (BVDV-1) is widespread in Australia and has been shown to contribute to BRD occurrence. As part of a prospective longitudinal study on BRD, effects of exposure to BVDV-1 on risk of BRD in Australian feedlot cattle were investigated. A total of 35,160 animals were enrolled at induction (when animals were identified and characteristics recorded), held in feedlot pens with other...[Show more]

dc.contributor.authorHay, K E
dc.contributor.authorAmbrose, R C K
dc.contributor.authorMorton, J M
dc.contributor.authorHorwood, P F
dc.contributor.authorGravel, J L
dc.contributor.authorWaldron, S
dc.contributor.authorCommins, M A
dc.contributor.authorFowler, E V
dc.contributor.authorBarnes, Tamsin S
dc.contributor.authorMahony, T J
dc.contributor.authorClements, Archie
dc.date.accessioned2016-06-14T23:19:25Z
dc.identifier.issn0167-5877
dc.identifier.urihttp://hdl.handle.net/1885/102880
dc.description.abstractViruses play a key role in the complex aetiology of bovine respiratory disease (BRD). Bovine viral diarrhoea virus 1 (BVDV-1) is widespread in Australia and has been shown to contribute to BRD occurrence. As part of a prospective longitudinal study on BRD, effects of exposure to BVDV-1 on risk of BRD in Australian feedlot cattle were investigated. A total of 35,160 animals were enrolled at induction (when animals were identified and characteristics recorded), held in feedlot pens with other cattle (cohorts) and monitored for occurrence of BRD over the first 50 days following induction. Biological samples collected from all animals were tested to determine which animals were persistently infected (PI) with BVDV-1. Data obtained from the Australian National Livestock Identification System database were used to determine which groups of animals that were together at the farm of origin and at 28 days prior to induction (and were enrolled in the study) contained a PI animal and hence to identify animals that had probably been exposed to a PI animal prior to induction. Multi-level Bayesian logistic regression models were fitted to estimate the effects of exposure to BVDV-1 on the risk of occurrence of BRD. Although only a total of 85 study animals (0.24%) were identified as being PI with BVDV-1, BVDV-1 was detected on quantitative polymerase chain reaction in 59% of cohorts. The PI animals were at moderately increased risk of BRD (OR 1.9; 95% credible interval 1.0–3.2). Exposure to BVDV-1 in the cohort was also associated with a moderately increased risk of BRD (OR 1.7; 95% credible interval 1.1–2.5) regardless of whether or not a PI animal was identified within the cohort. Additional analyses indicated that a single quantitative real-time PCR test is useful for distinguishing PI animals from transiently infected animals. The results of the study suggest that removal of PI animals and/or vaccination, both before feedlot entry, would reduce the impact of BVDV-1 on BRD risk in cattle in Australian feedlots. Economic assessment of these strategies under Australian conditions is required.
dc.publisherElsevier
dc.sourcePreventive Veterinary Medicine
dc.subjectBovine respiratory disease; Bovine viral diarrhoea virus 1; Feedlot cattle; Persistent infection; qPCR
dc.titleEffects of exposure to Bovine viral diarrhoea virus 1 on risk of bovine respiratory disease in Australian feedlot cattle
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume126
dc.date.issued2016
local.identifier.absfor070704 - Veterinary Epidemiology
local.identifier.ariespublicationU3488905xPUB11570
local.type.statusPublished Version
local.contributor.affiliationHay, K E, The University of Queensland
local.contributor.affiliationAmbrose, R C K, Department of Primary Industries and Fisheries, Animal Science
local.contributor.affiliationMorton, J M, Jemora Pty Ltd
local.contributor.affiliationHorwood, P F, Department of Primary Industries and Fisheries, Animal Science
local.contributor.affiliationGravel, J L, Department of Primary Industries and Fisheries, Animal Science
local.contributor.affiliationWaldron, S, Department of Primary Industries and Fisheries, Animal Science
local.contributor.affiliationCommins, M A, Department of Primary Industries and Fisheries, Animal Science
local.contributor.affiliationFowler, E V, Department of Primary Industries and Fisheries, Animal Science
local.contributor.affiliationClements, Archie, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBarnes, Tamsin S, University of Queensland
local.contributor.affiliationMahony, T J, The University of Queensland
local.description.embargo2037-12-31
local.bibliographicCitation.startpage159
local.bibliographicCitation.lastpage169
local.identifier.doi10.1016/j.prevetmed.2016.01.025
dc.date.updated2016-06-14T08:39:29Z
local.identifier.scopusID2-s2.0-84959921482
CollectionsANU Research Publications

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