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Can corruption of chromosome cohesion create a conduit to cancer?

Xu, Huiling; Tomaszewski, Jonathan; McKay, Michael

Description

Cohesin is a conserved multisubunit protein complex with diverse cellular roles, making key contributions to the coordination of chromosome segregation, the DNA damage response and chromatin regulation by epigenetic mechanisms. Much has been learned in recent years about the roles of cohesin in a physiological context, whereas its potential and emerging role in tumour initiation and/or progression has received relatively little attention. In this Opinion article we examine how cohesin...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/102826
Source: Nature Reviews: Cancer
DOI: 10.1038/nrc3018

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