Determination of Cefalothin and Cefazolin in Human Plasma, Urine and Peritoneal Dialysate by UHPLC-MS/MS: Application to a pilot pharmacokinetic study in humans
ABSTRACT: An ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) method for the analysis of cefazolin and cefalothin in human plasma (total and unbound), urine and peritoneal dialysate has been developed and validated. Total plasma concentrations are measured following protein precipitation and are suitable for the concentration range of 1–500 μg/mL. Unbound concentrations are measured from ultra-filtered plasma acquired using Centrifree® devices and are suitable...[Show more]
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