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Prefrontal cortex white matter tracts in prodromal Huntington disease

Matsui, Joy T.; Vaidya, Jatin G.; Wassermann, Demian; Kim, Regina Eunyoung; Magnotta, Vincent A.; Johnson, Hans J.; Paulsen, Jane S.; De Soriano, Isabella; Shadrick, Courtney; Miller, Amanda; Kumar, Rajeev


Huntington disease (HD) is most widely known for its selective degeneration of striatal neurons but there is also growing evidence for white matter (WM) deterioration. The primary objective of this research was to conduct a large-scale analysis using multisite diffusion-weighted imaging (DWI) tractography data to quantify diffusivity properties along major prefrontal cortex WM tracts in prodromal HD. Fifteen international sites participating in the PREDICT-HD study collected imaging and...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Human Brain Mapping
DOI: 10.1002/hbm.22835


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