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Immunoglobulin G replacement for the treatment of infective complications of rituximab-associated hypogammaglobulinemia in autoimmune disease: A case series

Roberts, Darren; Jones, Rachel B.; Smith, Rona M.; Alberici, Federico; Kumaratne, Dinakantha S.; Burns, Stella; Jayne, David R.W.


The anti-CD20 B cell depleting monoclonal antibody rituximab is being used increasingly for autoimmune diseases, including patients with refractory disease with extensive prior exposure to immunosuppressive treatments. Rituximab, in this context, may be associated with increased risk of adverse effects, in particular hypogammaglobulinemia which predisposes to recurrent infections necessitating Immunoglobulin G replacement. Outcome data following Immunoglobulin G replacement after rituximabin...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Autoimmunity
DOI: 10.1016/j.jaut.2014.11.004


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