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The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

Spillman, Natalie; Kirk, Kiaran


The intraerythrocytic malaria parasite, Plasmodium falciparum, maintains a low cytosolic Na+ concentration and the plasma membrane P-type cation translocating ATPase 'PfATP4' has been implicated as playing a key role in this process. PfATP4 has been the subject of significant attention in recent years as mutations in this protein confer resistance to a growing number of new antimalarial compounds, including the spiroindolones, the pyrazoles, the dihydroisoquinolones, and a number of the...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: International Journal for Parasitology: Drugs and Drug Resistance
DOI: 10.1016/j.ijpddr.2015.07.001


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