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High-sensitivity C-reactive protein (hs-CRP) as a biomarker for trastuzumab-induced cardiotoxicity in HER2-positive early-stage breast cancer: a pilot study

Onitilo, Adedayo A.; Engel, Jessica M.; Stankowski, Rachel V.; Liang, Hong; Berg, Richard; Doi, Suhail


Monitoring of left ventricular ejection fraction (LVEF) is the current standard for detection of trastuzumab-induced cardiotoxicity; however, time-to-diagnosis and cost of assessment are suboptimal in women with early-stage breast cancer. We assessed the utility of B-type natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), and cardiac troponin I (cTnI) as serum biomarkers for early detection of trastuzumab-induced cardiotoxicity. Fifty-four women with human epidermal growth...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Breast Cancer Research and Treatment
DOI: 10.1007/s10549-012-2039-z


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