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Adequate Lymph Node Recovery Improves Survival in Colorectal Cancer Patients

Onitilo, Adedayo A.; Stankowski, Rachel V.; Engel, Jessica M.; Doi, Suhail

Description

Introduction Current recommendations suggest recovery of 12 lymph nodes during surgical resection for colorectal cancer (CRC) for proper staging and prognostication. Adequate lymph node recovery has been associated with improved patient survival, with results inconsistent. Methods We examined factors for association with adequate lymph node recovery and used findings to adjust survival analyses to clarify whether adequate lymph node examination is associated with CRC survival or associated with...[Show more]

dc.contributor.authorOnitilo, Adedayo A.
dc.contributor.authorStankowski, Rachel V.
dc.contributor.authorEngel, Jessica M.
dc.contributor.authorDoi, Suhail
dc.date.accessioned2016-06-14T23:18:58Z
dc.identifier.issn0022-4790
dc.identifier.urihttp://hdl.handle.net/1885/102697
dc.description.abstractIntroduction Current recommendations suggest recovery of 12 lymph nodes during surgical resection for colorectal cancer (CRC) for proper staging and prognostication. Adequate lymph node recovery has been associated with improved patient survival, with results inconsistent. Methods We examined factors for association with adequate lymph node recovery and used findings to adjust survival analyses to clarify whether adequate lymph node examination is associated with CRC survival or associated with a subset of characteristics that biases lymph node recovery. Results In 74% of subjects (1,036/1,397) an adequate number of lymph nodes was examined. A stepwise multivariate regression analysis showed procedure year, cancer stage, tumor size, and age at diagnosis were significantly associated with lymph node recovery. These and other factors associated with survival status were adjusted for in further analyses, revealing no difference in unadjusted overall survival by adequacy of lymph node recovery (HR = 0.90, 95% CI: 0.75-1.08, P = 0.239). However, in adjusted Cox proportional hazards analysis, adequate lymph node recovery was associated with reduced risk for death (HR = 0.71, 95% CI: 0.57-0.89, P = 0.002). Conclusion The current recommendation for retrieval and examination of at least 12 lymph nodes is appropriate for proper treatment and prognostication in patients undergoing surgical resection for CRC.
dc.publisherAmerican Scientific Publishers
dc.sourceJournal of Surgical Oncology
dc.subjectKeywords: article; cancer staging; cancer surgery; cancer survival; colorectal cancer; female; groups by age; human; lymph node; major clinical study; male; mortality; outcome assessment; overall survival; priority journal; retrospective study; risk reduction; surv colorectal cancer; lymph node recovery; staging; survival
dc.titleAdequate Lymph Node Recovery Improves Survival in Colorectal Cancer Patients
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume107
dc.date.issued2013
local.identifier.absfor110300 - CLINICAL SCIENCES
local.identifier.absfor111700 - PUBLIC HEALTH AND HEALTH SERVICES
local.identifier.ariespublicationa383154xPUB2704
local.type.statusPublished Version
local.contributor.affiliationOnitilo, Adedayo A., Department of Hematology/Oncology, Marshfield Clinic Weston Center
local.contributor.affiliationStankowski, Rachel V., Marshfield Clinic Research Foundation
local.contributor.affiliationEngel, Jessica M., Stevens Point Cancer Center, Marshfield Clinic and Saint Michael’s Hospital
local.contributor.affiliationDoi, Suhail, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue8
local.bibliographicCitation.startpage828
local.bibliographicCitation.lastpage834
local.identifier.doi10.1002/jso.23332
dc.date.updated2016-06-14T08:31:06Z
local.identifier.scopusID2-s2.0-84878288307
CollectionsANU Research Publications

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