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Randomized clinical trial of the impact of insulin therapy on liver function in patients undergoing major liver resection

Hassanain, Mazen; Metrakos, Peter P.; Fisette, A.; Doi, Suhail; Schricker, T.; Lattermann, R.; Carvalho, G.; Wykes, L.; Molla, H.; Cianflone, K.

Description

Background: Postoperative liver dysfunction is the major source of morbidity and mortality in patients undergoing partial hepatectomy. This study tested the benefits of a metabolic support protocol based on insulin infusion, for reducing liver dysfunction following hepatic resection. Methods: Consecutive consenting patients scheduled for liver resection were randomized to receive preoperative dextrose infusion followed by insulin therapy using the hyperinsulinaemic normoglycaemic clamp...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/102696
Source: British Journal of Surgery
DOI: 10.1002/bjs.9034

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