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Variation in incidence of pediatric Crohn's disease in relation to latitude and ambient ultraviolet radiation: A systematic review and analysis

Holmes, Elizabeth; Xiang, Fan; Lucas, Robyn


Background: Pediatric Crohn's disease (CD) is a lifelong, debilitating, and costly disease. In previous studies, CD incidence increased with higher geographic latitude in the Northern Hemisphere. This may indicate a role for lower vitamin D status as a risk factor for CD. Analysis of worldwide incidence of pediatric CD has not been previously reported. Methods: We undertook a systematic review of population-based studies reporting incidence of pediatric CD and published between 2003 and 2013....[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Inflammatory Bowel Diseases
DOI: 10.1097/MIB.0000000000000320


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