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AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo

Devlin, Jennifer; Hannan, Katherine; Ng, Pui Y.; Bywater, Megan J.; Shortt, Jake; Cullinane, C; McArthur, Grant; Johnstone, Ricky; Hannan, Ross; Pearson, Richard B


The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high proportion of human cancers, and together they form a 'super signalling' network mediating malignancy. A fundamental downstream action of this signalling network is up-regulation of ribosome biogenesis and subsequent alterations in the patterns of translation and increased protein synthesis, which are thought to be critical for AKT/MYC-driven oncogenesis. We have demonstrated that AKT and MYC...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: The FEBS Journal
DOI: 10.1111/febs.12135


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