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Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches

George, Amee; Hannan, Ross; Thomas, Walter G.


To influence physiology and pathophysiology, G protein-coupled receptors (GPCRs) have evolved to appropriate additional signalling modalities, such as activation of adjacent membrane receptors. Epidermal growth factor receptors (EGFRs) mediate growth and remodelling actions of GPCRs, although the precise network of gene products and molecular cascades linking GPCRs to EGFRs (termed EGFR transactivation) remains incomplete. In this review, we describe the current view of GPCR-EGFR...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: The FEBS Journal
DOI: 10.1111/febs.12509


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