Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches
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George, Amee; Hannan, Ross; Thomas, Walter G.
Description
To influence physiology and pathophysiology, G protein-coupled receptors (GPCRs) have evolved to appropriate additional signalling modalities, such as activation of adjacent membrane receptors. Epidermal growth factor receptors (EGFRs) mediate growth and remodelling actions of GPCRs, although the precise network of gene products and molecular cascades linking GPCRs to EGFRs (termed EGFR transactivation) remains incomplete. In this review, we describe the current view of GPCR-EGFR...[Show more]
Collections | ANU Research Publications |
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Date published: | 2013 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/102570 |
Source: | The FEBS Journal |
DOI: | 10.1111/febs.12509 |
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File | Description | Size | Format | Image |
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01_George_Unravelling_the_molecular_2013.pdf | 263.8 kB | Adobe PDF | Request a copy |
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