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Applications of paramagnetic NMR spectroscopy in drug discovery

Chen, Wan-Na

Description

NMR spectroscopy of proteins with paramagnetic metal ions, first performed with metalloproteins, is a unique technique to obtain long-range distance information for three-dimensional structure determinations. This thesis focuses on developing applications of paramagnetic NMR spectroscopy, particularly pseudocontact shifts, in drug discovery. The two-component dengue virus NS2B-NS3 protease (NS2B-NS3pro) from serotype 2 is a well-established drug target, but...[Show more]

CollectionsOpen Access Theses
Date published: 2016
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/101990
DOI: 10.25911/5d78d57314dc7

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