The role of heparan sulfate in poxvirus infections
The heparan sulfate (HS) component of heparan sulfate proteoglycans (HSPGs) has been implicated in the initiation of several viral infections, including vaccinia virus (VACV). A cell infected with VACV releases two different forms of VACV, namely the mature virus (MV) released following the death of infected cells and which infects neighbouring cells, and the enveloped virus (EV) ejected from infected cells for long-range dissemination. The relative role of HS in the infectivity of the...[Show more]
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