Ashby-Mitchell, Kimberly
Description
The prevalence of moderate or severe cognitive impairment (CIm)
rises steeply with age. It is well documented that our
populations (both in developed and low- and middle-income
countries) are ageing and that lifestyle factors may hold the key
to preserving mental and functional status. This thesis adopts a
cross-national approach between Australia and seven Latin
American and Caribbean (LAC) countries and focuses on two
modifiable lifestyle factors – diet and...[Show more] physical activity.
Two data sets are utilised in this thesis – the Australia
Diabetes, Obesity and Lifestyle Study (AusDiab)and the Survey on
Health, Well-Being, and Ageing in LAC (SABE). AusDiab represents
the largest Australian longitudinal population-based study
examining the natural history of diabetes, pre-diabetes, heart
disease
and kidney disease. Three Waves of data have been collected thus
far with cognitive function examined at the most recent Wave
only. The SABE is a 7-country survey conducted in LAC in 2000.
The SABE represents the only comprehensive health-related data
set for persons over the age of 60 in the region that takes into
account cognitive status.
Using the Sullivan Method for calculating health expectancies, it
was found that in Australia females live longer than males and
males spend more time with CIm. In LAC, substantial differences
in the absolute years lived and the proportion of remaining life
spent free of CIm were observed. Total life expectancy (TLE) and
cognitive impairment-free life expectancy (CIFLE) at age 60 years
were highest in Brazil and Mexico and lowest in Uruguay and
Cuba.
Both a priori and a posteriori methods were used to examine the
relationship between diet, physical activity and cognition. In
the first instance, greater adherence to the Mediterranean Diet
(MeDi), engagement in physical activity, and television viewing
time were not predictive of CIm among older adults in the
Australian sample.
In the second instance using principal component analysis (PCA),
complex patterns of associations between dietary factors and
cognition were evident in the Australian sample. The most
consistent finding was the protective effects of high vegetable
and plant-based food item consumption and negative effects of
‘Western’
patterns on cognition. Among LAC countries, weekly consumption of
milk and cheese, eggs, peas and beans, meat, fish or poultry, and
fruits or vegetables were significantly associated with CIm.
Regular exercise or participation in vigorous physical activity
such as playing a sport, dancing or heavy housework three or
more times a week was significantly associated with CIm in Chile,
Mexico and Uruguay.
Using a modified population attributable risk formula which
accounts for non-independence of risk factors, an estimated 39.0%
of dementia cases in Australia may be attributable to five
modifiable risk factor (excess alcohol consumption, midlife
obesity, physical inactivity, smoking and low educational
attainment). In the LAC region, diabetes mellitus, physical
inactivity and smoking were estimated to be attributable to 21.9%
of cases in Barbados, 14.7% in Mexico, and 26.2% in Cuba. If each
risk factor were to be reduced by 10% and 20% every 10 years to
2050, dementia prevalence could be reduced by up to 24.7% in
Australia and up
to 16.3% in LAC countries.
This thesis highlights the need for greater investment in
research, interventions and policies targeting modifiable
lifestyle factors to reduce CIm risk factor prevalence at the
population level. In addition, the need for more research in the
LAC region (particularly longitudinal studies) is highlighted.
Overall, the findings suggest that there is a need for further
studies to better understand more nuanced topics, such as the
effect of composite dietary patterns on cognitive decline and the
nutrition-cognition link in different populations, as there is a
general paucity of data sources designed to address these issues.
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