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Increasing incidence of glioblastoma multiforme and meningioma, and decreasing incidence of Schwannoma (2000-2008): Findings of a multicenter Australian study

Khurana, Vini G.; Jain, Sanjiv; Smee, Robert; Cook, Raymond; Dobes, Martin; Shadbolt, Bruce; Smith, Sarah F.; Dexter, Mark

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BACKGROUND The incidence of primary brain tumors by subtype is currently unknown in Australia. We report an analysis of incidence by tumor subtype in a retrospective multicenter study in the state of New South Wales (NSW) and the Australian Capital Territory (ACT), with a combined population of >7 million with >97% retention rate for medical care. METHODS Data from histologically confirmed primary brain tumors diagnosed from January 2000 through December 2008 were weighted for patient outflow...[Show more]

dc.contributor.authorKhurana, Vini G.
dc.contributor.authorJain, Sanjiv
dc.contributor.authorSmee, Robert
dc.contributor.authorCook, Raymond
dc.contributor.authorDobes, Martin
dc.contributor.authorShadbolt, Bruce
dc.contributor.authorSmith, Sarah F.
dc.contributor.authorDexter, Mark
dc.date.accessioned2016-04-19T06:18:57Z
dc.date.available2016-04-19T06:18:57Z
dc.identifier.issn2152-7806
dc.identifier.urihttp://hdl.handle.net/1885/101063
dc.description.abstractBACKGROUND The incidence of primary brain tumors by subtype is currently unknown in Australia. We report an analysis of incidence by tumor subtype in a retrospective multicenter study in the state of New South Wales (NSW) and the Australian Capital Territory (ACT), with a combined population of >7 million with >97% retention rate for medical care. METHODS Data from histologically confirmed primary brain tumors diagnosed from January 2000 through December 2008 were weighted for patient outflow and data completeness, and age standardized and analyzed using joinpoint analysis. RESULTS A significant increasing incidence in glioblastoma multiforme (GBM) was observed in the study period (annual percentage change [APC], 2.5; 95% confidence interval [CI], 0.4-4.6, n = 2275), particularly after 2006. In GBM patients in the ≥65-year group, a significantly increasing incidence for men and women combined (APC, 3.0; 95% CI, 0.5-5.6) and men only (APC, 2.9; 95% CI, 0.1-5.8) was seen. Rising trends in incidence were also seen for meningioma in the total male population (APC, 5.3; 95% CI, 2.6-8.1, n = 515) and males aged 20-64 years (APC, 6.3; 95% CI, 3.8-8.8). Significantly decreasing incidence trends were observed for Schwannoma for the total study population (APC, -3.5; 95% CI, -7.2 to -0.2, n = 492), significant in women (APC, -5.3; 95% CI, -9.9 to -0.5) but not men. CONCLUSION This collection is the most contemporary data on primary brain tumor incidence in Australia. Our registries may observe an increase in malignant tumors in the next few years that they are not detecting now due to late ascertainment. We recommend a direct, uniform, and centralized approach to monitoring primary brain tumor incidence by subtype, including the introduction of nonmalignant data collection.
dc.description.sponsorshipThis study was funded by the Private Practice Fund of the Canberra Hospital, Australia
dc.publisherMedknow Publications
dc.rights© 2011 Dobes M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourceSurgical Neurology International
dc.subjectaustralia
dc.subjectcancer
dc.subjectincidence
dc.subjectlate ascertainment
dc.subjectprimary brain tumor
dc.titleIncreasing incidence of glioblastoma multiforme and meningioma, and decreasing incidence of Schwannoma (2000-2008): Findings of a multicenter Australian study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume2
dc.date.issued2011
local.identifier.absfor111706
local.identifier.ariespublicationu4971216xPUB58
local.publisher.urlhttp://www.medknow.com/
local.type.statusPublished Version
local.contributor.affiliationDobes, Martin, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National University
local.contributor.affiliationKhurana, Gautam (Vini), College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National University
local.contributor.affiliationShadbolt, Bruce, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National University
local.contributor.affiliationJain, Sanjiv, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National University
local.contributor.affiliationSmith, Sarah F, Royal North Shore Hospital, Australia
local.contributor.affiliationSmee, Robert, Prince of Wales Hospital, Australia
local.contributor.affiliationDexter, Mark, Children's Hospital at Westmead , Australia
local.contributor.affiliationCook, Raymond, Royal North Shore Hospital, Australia
local.identifier.essn2152-7806
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage176
local.bibliographicCitation.lastpage176
local.identifier.doi10.4103/2152-7806.90696
local.identifier.absseo970111
dc.date.updated2016-06-14T09:10:55Z
local.identifier.scopusID2-s2.0-84863092330
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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