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The β₁ₐ Subunit of the Skeletal DHPR Binds to Skeletal RyR1 and Activates the Channel via Its 35-Residue C-Terminal Tail

Rebbeck, Robyn T.; Karunasekara, Yamuna; Gallant, Esther M.; Board, Philip G.; Beard, Nicole A.; Casarotto, Marco G.; Dulhunty, Angela F.


Although it has been suggested that the C-terminal tail of the β₁ₐ subunit of the skeletal dihyropyridine receptor (DHPR) may contribute to voltage-activated Ca²⁺ release in skeletal muscle by interacting with the skeletal ryanodine receptor (RyR1), a direct functional interaction between the two proteins has not been demonstrated previously. Such an interaction is reported here. A peptide with the sequence of the C-terminal 35 residues of β₁ₐ bound to RyR1 in affinity chromatography. The...[Show more]

CollectionsANU Research Publications
Date published: 2011-02-16
Type: Journal article
Source: Biophysical Journal
DOI: 10.1016/j.bpj.2011.01.022


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