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Angiotensinogen and transforming growth factor  1: novel genes in the pathogenesis of Crohn's disease

Hume, G E; Fowler, E V; Lincoln, D; Eri, R; Templeton, D; Florin, T H; Cavanaugh, J A; Radford-Smith, G L


BACKGROUND Angiotensin peptides may act locally as cytokines in several organ systems with elevated mucosal levels present in Crohn's disease. A variant in the angiotensinogen gene promoter results in increased peptide production, while transforming growth factor beta1 (TGFbeta1) codon 25 variants demonstrate variable peptide production, predisposing to fibrosis in several organs. AIMS Conduct an Australian-based analysis of the angiotensinogen-6 variant in two independent inflammatory bowel...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Medical Genetics
DOI: 10.1136/jmg.2005.040477


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